| Pick | Team | Player | Position | School | Height | Weight |
| 1 | Arizona | Nick Bosa* | DE | Ohio State | 6' 4" | 265 |
| 2 | San Francisco | Josh Allen | OLB | Kentucky | 6' 5" | 230 |
| 3 | NY Jets | Quinnen Williams** | DE | Alabama | 6' 4" | 290 |
| 4 | Oakland | Rashan Gary* | DE | Michigan | 6' 5" | 287 |
| 5 | Tampa Bay | Dwayne Haskins** | QB | Ohio State | 6' 3" | 218 |
| 6 | NY Giants | Daniel Jones* | QB | Duke | 6' 5" | 215 |
| 7 | Jacksonville | Drew Lock | QB | Missouri | 6' 4" | 220 |
| 8 | Detroit | Jonah Williams* | OT | Alabama | 6' 5" | 301 |
| 9 | Buffalo | T.J. Hockenson** | TE | Iowa | 6' 5" | 245 |
| 10 | Denver | Jawaan Taylor* | OT | Florida | 6' 5" | 334 |
| 11 | Cincinnati | Kyler Murray* | QB | Oklahoma | 5' 10" | 195 |
| 12 | Green Bay | Josh Jacobs* | RB | Alabama | 5' 10" | 216 |
| 13 | Miami | Ed Oliver* | DT | Houston | 6' 3" | 290 |
| 14 | Atlanta | Clelin Ferrell* | DE | Clemson | 6' 5" | 260 |
| 15 | Washington | Greedy Williams** | CB | LSU | 6' 2" | 185 |
| 16 | Carolina | Christian Wilkins | DT | Clemson | 6' 4" | 310 |
| 17 | Cleveland | Jeffrey Simmons* | DT | Mississippi State | 6' 4" | 301 |
| 18 | Minnesota | Andre Dillard | OT | Washington State | 6' 5" | 310 |
| 19 | Tennessee | Devin White* | ILB | LSU | 6' 1" | 255 |
| 20 | Pittsburgh | Jachai Polite* | DE | Florida | 6' 2" | 245 |
| 21 | Seattle | Cody Ford* | OG | Oklahoma | 6' 4" | 335 |
| 22 | Baltimore | Montez Sweat | DE | Mississippi State | 6' 6" | 260 |
| 23 | Houston | Dalton Risner | OT | Kansas State | 6' 5" | 300 |
| 24 | Oakland | Marquise Brown* | WR | Oklahoma | 5' 11" | 165 |
| 25 | Philadelphia | Greg Little* | OT | Mississippi | 6' 6" | 325 |
| 26 | Indianapolis | Jaylon Ferguson | DE | Louisiana Tech | 6' 5" | 255 |
| 27 | Oakland | Brian Burns* | DE | Florida State | 6' 5" | 218 |
| 28 | LA Chargers | Deandre Baker | CB | Georgia | 5' 11" | 180 |
| 29 | Kansas City | Noah Fant* | TE | Iowa | 6' 4" | 235 |
| 30 | Green Bay | Byron Murphy** | CB | Washington | 5' 11" | 170 |
| 31 | LA Rams | Mack Wilson* | ILB | Alabama | 6' 2" | 239 |
| 32 | New England | Nassir Adderley | S | Delaware | 5' 11" | 190 |